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In the cellular component category, several key cellular components were identified, such as cell part, membrane and ribosome.
Analyses of hepatic transcriptional fingerprints led to the identification of several key cellular pathways affected by ritonavir treatment.
Furthermore, some anti-cancer agents like piperlongumine bind to the active sites of several key cellular antioxidants including glutathione S transferase and carbonyl reductase 1 only in the cancer cells.
During the past several years, new evidence begins to emerge on a functional link between these signaling pathways and several key cellular events such as autophagy and the function of ER and/or mitochondria, shedding light on the mechanisms by which suppressing insulin/IGF-1 and mTOR signaling pathways leads to improved longevity and healthy aging (Fig. 2).
miRNAs are emerging as important gene regulators and intensive research of their functions and targets have revealed a role of miRNAs in several key cellular functions.
H-Ras is a binary switch that is activated by multiple co-factors and triggers several key cellular pathways one of which is MAPK.
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Excess mechanical force and deformation causes structural and functional breakdown, including several key deleterious cellular processes, such as membrane damage, an upset of calcium homeostasis, glutamate release, cell death, and caspase-mediated proteolysis.
Furthermore, in addition to many uncharacterized transcripts, AtNHX1 also showed an impact on the transcription of several other key cellular processes including: sulfur metabolism, vesicular trafficking, protein processing, energy transfer processes, and cell growth/structure.
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that plays key roles in several fundamental cellular processes.
These mechanisms have been partially delineated using chronically infected cell models and, clearly, HIV-1 activation from latency involves several key viral and cellular components.
This has implication for disease pathogenesis, since the PARK proteins influence several key pathways of cellular function including oxidative phosphorylation, apoptosis, synaptic transmission, and transmission of nerve impulse, all pathways that seem to be more affected in male PD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com