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It is produced in several isoforms that differ in their N-terminal signal peptide and C-terminal extension peptide.
Vertebrate agrins exist in several isoforms that are generated by alternative splicing (Figure 1).
For example, the CCAAT/enhancer binding protein β [43] and the G-protein signaling-2 protein [44] both have several isoforms that vary at their amino termini and are associated with distinctive biological activities.
Tropomyosin has several isoforms that are cell cycle dependant [ 76, 77].
Similar to Erg, murine Gata4 encodes several isoforms that are expressed in multiple tissues.
Vimentin is also known to have several isoforms that are distinguishable by 2D gel analyses.
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Many organisms have several MHC isoforms that fulfill various functions and differ in their expression patterns.
The leptin receptor is a single transmembrane protein and has several alternatively spliced isoforms (one long isoform and several short isoforms) that are distributed in many tissues [ 7, 8].
In addition, plants may contain several CaM isoforms that differ in only a few amino acids, with one of the isoforms being encoded by several genes located on different chromosomes of the genome.
The similarity of human carbonic anhydrase (CA) active sites makes it difficult to design selective inhibitors for one or several CA isoforms that are drug targets.
In this study, we identified several NUMB isoforms that are differently expressed in dental tissues.
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