FGFRs have several isoforms as exon skipping removes the Ig-I domain.
PEDF is naturally present in several isoforms as revealed by isoelectric focusing (Tombran-Tink et al., 1995).
There are several isoforms as products of different genes, coined alpha, beta and gamma actin, all of which are polymorphic proteins capable to form polymers. "Conventional actins" display a particular fold which enables them to interact with a variety of partners, to form specific suprastructures involved in intracellular motility, adhesion and locomotion (see below).
Heterogeneous mitochondrial network alterations in glioma cells and in microvascular environment are implicated directly and indirectly in the processes linked to hypoxia-tolerant and hypoxia-sensitive cells phenotype, effects of the hypoxia-inducible factor-1α, increased expression of several glycolytic protein isoforms as well as fatty acid synthase, and survivin.
This cluster is enriched in auxin signaling transcripts (ARF5, ARF5-like, IAA13, auxin transport protein BIG and BIG-like), starch metabolism transcripts (alpha amylase, isoamylase, glucan:water dikinase), several callose synthase isoforms, as well as two almost identical cytoplasmic acetyl-CoA carboxylase 1 transcripts encoding ACCases involved in flavonoid biosynthesis.
The VEGFA is the most abundant member of the VEGF family (Holmes and Zachary, 2005; Yamazaki and Morita, 2006), which comprising several isoforms, such as VEGF165, through alternative splicing.
These transporters are part of the superfamily of glucose transporters encoded by the GLUT genes; there are several isoforms, such as GLUT4, and their expression on the cell surface is amplified by insulin [ 21].
Increased adiponectin, a cytokine that exists in several isoforms and that originates from fat as well as other tissues, has been associated with reduced risk of metabolic syndrome in the elderly (Lim et al. 2010; Stenholm et al., 2009).
U2OS and SaOS-2 were chosen due to increased expression of LRP5 receptor and several isoforms of the FZD receptor 29, as well as reduced expression of WIF1 31, 31, resulting in aberrant activation of Wnt/ β-catenin signaling.
Furthermore, expression of the PP1 isoforms as well as several genes encoding BRCA1 interacting proteins was analyzed in primary human invasive breast tumors.
Both human breast cancer (HBC) cell lines and HME cells expressed two FGFR2 isoforms, whereas SUM-52PE cells overexpressed those two isoforms, as well as several unique FGFR2 polypeptides.
