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29 Where studies had multiple comparisons (several intervention arms or reported outcomes for different behaviours) or were cRCTs, we adjusted participant numbers in line with Cochrane recommendations where possible.
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Several trials included multiple intervention arms [39, 71, 72, 87] resulting in a total of 72 individual exercise interventions.
Similarly, for three-armed trials 17 18 that compared two similar intervention arms with one control arm, the intervention arms were combined and compared with the control arm.
Several factors probably contributed to the lack of statistical significance for the difference between the two intervention arms.
The TTM-trial differs from previous trials in several aspects, the most important one being that all patients received controlled temperature management avoiding fever in both intervention arms (Fig. 6).
The TTM-trial differs from previous trials in several aspects, the most important one being that all patients received controlled temperature management avoiding fever in both intervention arms (Fig. 6).
Outcome findings revealed that youth assigned to the computer or conventional intervention arms achieved more positive pretest-to-posttest gain scores than youth in the control arm on several variables.
Several promising therapies assessed in the adult critically ill in large, multicenter randomized controlled trials (RCTs) were associated with significantly increased mortality in the intervention arms.
Eight randomized control trials with 17 intervention arms were included.
The primary results showed very wide ranges of intervention and control mortality rates (intervention arms: 25.7 59 %, mean 29.9%%, versus control arms: 17 49 %, mean 25%%) (Table 2; Fig. 1).
Where multiple intervention arms were compared with usual care within a single study, each exercise arm was considered a separate intervention and data extracted accordingly.
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