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Egr-1 was also shown to positively regulate several inflammatory responses.
Signal transduction mediated by ceramide leads cells to produce cytokine induced apoptosis during several inflammatory responses.
Sphingosine kinases are novel enzymes that phosphorylate sphingosine (a membrane lipid), to generate the bioactive molecule sphingosine-1-phosphate (SPP), which is implicated in several inflammatory responses.
Moreover, increasing evidence has shown that viral infections such as Japanese encephalitis virus (JEV) and Enterovirus 71 (EV71) may contribute to several inflammatory responses in CNS [ 28].
Macrophage Inflammatory Protein-1α (MIP-1α) belongs to the group of CC chemokines that regulate several inflammatory responses including trafficking and activation of leukocytes, as well as the fever response [ 98].
These peptides mediate several inflammatory responses including increasing vasodilatation and vascular permeability, promotion of fluid secretion and ion transport, and eliciting itching and pain at the sites exposed to noxious stimuli.
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Several inflammatory response materials could be used for prediction of prognosis of cancer patients.
Several inflammatory response and antigen presentation genes were upregulated and their expression increased with the progression of the disease.
Moreover, the upregulation of several inflammatory response genes after treatment with inflammatory stimuli was drastically reduced in Parp1 knockout mice [ 112, 114- 116].
On the other hand, it is well known that the UPR has been linked to several inflammatory response pathways in many cellular models and diseases.
Several other inflammatory response genes induced with diabetes were also not rescued by insulin treatment.
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