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The inflamed airways of COPD patients contain several inflammatory cells including neutrophils, macrophages,T lymphocytes, and dendritic cells (DCs).
Various groups have reported IL-6 gene expression and secretion by cytokine-stimulated human RPE cells [37], [38], whereas IL-6 may also be produced by several inflammatory cells invading the subretinal space after RRD due to chemotactic signalling [39].
Connective tissue ingrowing from the periphery of the tumor was observed and several inflammatory cells were found there beside fibroblasts.
Several inflammatory cells externalize a meshwork of chromatin fibers, containing citrullinated histones, decorated with granule-derived (antimicrobial) proteins.
The pathology of rheumatoid arthritis (RA) is characterized by the infiltration of several inflammatory cells into both the pannus and the joint fluid, and by subsequent tissue destruction.
In vivo, a significant part of macrophage effector responses occurs through cell-contact-dependent signalling with several inflammatory cells, mainly T cells and fibroblasts.
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Several inflammatory cell types express PPARβ/δ.
PP-increased DEGs were not significantly enriched with respect to several inflammatory cell types, such as CD4+ T-cells and dendritic cells.
It has been shown that inhibition of PDE4D enhances intracellular cAMP, which controls several inflammatory cell functions [ 90], and increased levels of cAMP induce apoptosis and cell cycle arrest in cancer cells [ 91].
RANKL is present at high levels in RA synovial tissues as compared with healthy or osteoarthritic synovial tissues [ 6], and several inflammatory cell types are probably responsible for ectopic production of RANKL in synovial tissues adjacent to bone.
In addition to lymphocytes, recent studies demonstrate that CD45 can modulate activation and proliferation of several inflammatory cell types including granulocytes, mast cells and monocyte-lineage cells, broadening its role as a regulator of inflammatory responses (8, 20, 35, 48, 57).
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