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We analyzed several independent microarray datasets, to identify a predictor, use it to classify unclassifiable sarcomas, and assess oncogenic pathway activation and chemotherapy response.
Several independent microarray studies have been carried out to investigate global gene expression in response to blue light [23] [26].
Intriguingly, there is a clear inverse correlation between AIF and WNT/β-catenin signaling target genes in several independent microarray datasets from different types of cancers.
The meta-analysis data set represents a composite of several independent microarray studies, which minimizes the likelihood of sex-biased transcription misclassification for each gene (compared with classifications based on single studies).
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+ HJURP expression is measured as log2 (probe intensities) by Affymetrix microarray To validate our findings, we used several independent breast cancer cohorts with previously reported microarray data deposited in the Gene Expression Omnibus (GEO) database [ 17], to compare mRNA level of HJURP in tumor tissue with patient survival (Table 3).
Through a rigorous statistical approach, data from several independent L. infantum and L. major DNA microarray experiments were compiled and compared here.
Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to mitigate the detrimental effects of gene dose differences.
JA-responsive SAGs have been identified in independent microarray studies [ 55- 57] including several genes in the jacalin lectin gene family.
S100A16 mRNA levels were positively correlated with mRNA levels of several of the differentiation markers (IVL, KRT13, TGM1 and FLG) in two independent microarray datasets [ 20, 21] (Fig. 3a– d and Additional file 4: Figure S3).
This enrichment was further validated in the independent microarray datasets (Supplementary Fig. 25).
Examining the four independent microarray cohorts strongly validated the NAT-specific activation of the identified TASA genes (Fig. 4d; Supplementary Figs. 14 17).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com