Sentence examples for several human pathologies from inspiring English sources
Uncontrolled cell death is associated with several human pathologies, such as neurodegenerative diseases and ischemic injuries.
Given the importance of developmental regulation and tissue maintenance, defects in Cdc48 activity have been linked to several human pathologies including protein aggregation diseases.
Nuclear Factor kappaB (NF-κB) plays a very important role in the control of gene expression and is deeply involved in several human pathologies.
Increased levels of TG2 are observed in several human pathologies including neurodegenerative diseases such as Alzheimer's, Huntington's, and Parkinson's diseases, as well as in chronic inflammatory conditions [24 26].
Finally, septin dysfunction has been associated with several human pathologies, including cancer [29], Parkinson's disease [30], Alzheimer's disease [31] and hereditary neuralgic amyotrophy [32].
More than 10 HDACis are tested in various phases of clinical trials for several human pathologies.
The success of the proteasome inhibitor bortezomib (Velcade®) as a new drug for the treatment of Multiple Myeloma, and the ongoing clinical trials to evaluate the effect of several other proteasome inhibitors in various human pathologies, illustrate the interest for human health of these compounds.
Elevated levels of OSM have been detected in several human CNS pathologies, such as multiple sclerosis, HIV-associated dementia, and epileptic seizure [14], [15], [16].
The function of this stable RNA species is currently unknown, but its accumulation has been described in several human mitochondrial pathologies (Suzuki et al., 2011).
IL-21 has now been linked to several human autoimmune pathologies including SLE, psoriasis, Sjögren's syndrome, MS and RA, making this cytokine an attractive target for therapeutic intervention [ 160, 180- 186].
In this review, we demonstrate the use of lipidomics and the corresponding analytical tools to highlight the most recent information and evidences that LC-PUFAs participate in several major human pathologies.
