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ARF4 knockdown cells show increased resistance to several human pathogens including Chlamydia trachomatis and Shigella flexneri.
Rapid diagnostics are not available for several human pathogens in the genus Phlebovirus of the Bunyaviridae.
Role of biofilms in the pathogenesis of several human pathogens is well established.
In the former case, the SAM-I riboswitch is an attractive target because this structured RNA element is found only in bacterial mRNAs and regulates multiple genes in several human pathogens.
The North American beaver (Castor canadensis) is a zoonotic reservoir for several human pathogens including Cryptosporidium spp. and Giardia spp. In order to specifically detect fecal pollution by beavers, we have developed and validated a beaver-specific Bacteroidales marker, designated Beapol01, based on the 16S rRNA gene.
Fatty acids of linolenic acid (Ohta et al. 1994), palmitoleic acid and hexadecatrienoic acid (HTA) (Desbois et al. 2008), and eicosapentaenoic acid (EPA) (Desbois et al. 2009) were also identified as antimicrobial agents against several human pathogens.
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Several human-pathogen interaction networks have been reported, such as Plasmodium falciparum, Yersinia pestis, hepatitis C virus (HCV), and Epstein-Barr virus (EBV) [ 13– 16].
Whole genome shotgun sequencing using 454 Life Sciences' next-generation pyrosequencing technology has been used in our laboratory to obtain high-coverage draft genomic DNA sequence datasets for large numbers of strains of several human bacterial pathogens [ 21- 23].
The family Flaviviridae comprises several major human pathogens including hepatitis C virus (genus hepacivirus), yellow fever virus, West Nile virus and dengue virus (genus flavivirus).
Several important human pathogens, including Pseudomonas aeruginosa [27], Salmonella enterica [28], [29], Staphylococcus aureus [30], and E. coli [31], have been investigated using C. elegans.
HCV is a plus-strand RNA virus belonging to the Flaviviridae family of viruses, which include several other human pathogens such as West Nile (WNV) and Dengue viruses [3].
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