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Several human disorders caused by mutations in genes coding for enzymes dealing with GlcNAc have been identified.
More recently, oxidative folding has been discovered as one important mechanism for mitochondrial proteostasis whilst several human disorders have been linked to this pathway.
Cathepsins play an important role in several human disorders and therefore the design and synthesis of their inhibitors attracts considerable interest in current medicinal chemistry approaches.
Vaccine- and gene-based drug development play a vital role in the field of community medicine for diagnosis and prophylaxis of several human disorders including cancer, HIV, malaria, influenza, and diabetes mellitus, etc.
These characteristics, together with the absence of ethical issues concerning their employment, suggest that stem cells present in the amniotic fluid might be promising candidates for tissue engineering and stem cell therapy of several human disorders.
The resulting profiles are determinant in normal developmental processes as well as in several human disorders [1], [2].
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However, extension of trinucleotide microsatellite sequences has been associated with several severe human disorders, such as Fragile X syndrome and Huntington's disease.
Specifically, neural development is also of great clinical relevance because several human neuropsychiatric disorders such as schizophrenia, autism disorders or drug addiction and also brain malformations are thought to have neurodevelopmental origins, i.e. pathogenesis initiates during childhood and adolescence.
Mitochondrial dysfunctions occur in several human inherited disorders [20].
These defects are similar in presentation to several human craniofacial disorders (e.g., craniosynostosis, hemifacial microsomia), and may be related to increased levels of bone metabolism observed in aceti282a/fgf8 heterozygotes.
This mechanism underlies several human genomic disorders, contributes to tumorigenesis, and has played a major role in primate karyotype evolution [19], [20].
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