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For example, several haplotypes in IL10RA are at or near significant levels meeting our criteria, but all of the haplotypes showing suggestive evidence of haplotype association contain the marker rs4252279 (Table S3).
In conclusion, several haplotypes in the 3' end of the PAX6 locus were found to be associated with high myopia in both the initial study and the replication study involving Han Chinese subjects.
Several haplotypes in both genes were shared by multiple species from Bos and Bison.
Four of five populations harboured a population-specific high-frequency haplotype; the exception, P2, comprised several haplotypes in similar proportions.
The PNNK population of Guinea baboons was characterized by a high mitochondrial haplotype diversity within communities, as expected for species with female dispersal [Städele et al., 2015], which leads to the accumulation of several haplotypes in single localities.
Nevertheless, the ability to detect a true disease variant using a haplotype approach can be attenuated if the variant is distributed across several haplotypes in the population and the Ile105Val allele is split into two major haplotypes in Hispanic whites.
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In fact, several haplotypes localized in the 5′-IGS/ETS built with the developed program were also detected and validated using cloning/(re -sequencing in the Spare -sequencingbetween S. marinima and S. altheniflora (Spartinansendii and S. x neyrautii; unpublishybridsa).
The distribution of most haplotypes was geographically confined, but one haplotype was widely distributed throughout northern Japan, and several haplotypes were found in geographically distant regions.
Several haplotypes were overrepresented in patients compared with controls, but only 1A 10 (P = 0.00007, OR = 6.58; 95% CI 2.24 to 26.22) remained significant after Bonferroni correction.
In a soft sweep, individuals that carry the adaptive allele collapse into distinct clusters in the genealogy and several haplotypes can be frequent in the population.
Within these two major lineages, several haplotypes are also found in the invaded areas (America and Europe), e.g. haplotype FW1 in North America and haplotype FW5 in America and Europe [ 31] (Table 1).
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