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Several genetic variations have been associated with asthma severity in children, including those within genes coding for filaggrin [ 4], macrophage inhibitory factor [ 5], interleukin-4 [ 6] and the beta 2 adrenoceptor [ 7].
But recent genomic studies have identified several genetic variations that contribute heavily to the disease.
Several genetic variations have been identified in association with abnormal uric acid metabolism.
Several genetic variations have been proposed to play a role in giving African athletes a possible advantage in endurance sports.
Scientists have already uncovered several genetic variations that raise risk for ADHD, which is likely caused by a complex combination of genetic and other factors.
Unlike the rare diseases caused by a change affecting only one gene, common diseases like cancer and diabetes are caused by a set of several genetic variations in each person.
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Several genetic variation parameters were calculated using GenAlEx version 6.5 (Peakall and Smouse [2012]), including the number of alleles (Na), the number of effective alleles (Ne), the observed and expected heterozygosity (Ho and He), Shannon's information index (H), fixation index (F IS ).
Furthermore, the authors identified two cases of co-inheritance of several independent genetic variations that influence the abundance of related proteins in a biologically coherent manner.
Besides the 7-amino acid deletion in p6gag, several characteristic genetic variations were also observed in pCRF07_BC and most CRF07_BC sequences, and their roles in slow immunological progression cannot be neglected.
We work at several levels: genetic variation within populations, local adaptation among populations, and the evolution of species differences.
On the other hand, if our diet had been constant over a longer period (e.g. several generations), genetic variation should rather have been considered 'root cause' of variation in obesity.
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