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Furthermore, in GSEA analysis conducted over the gene expression of the CRC cohort, we could identify several gene sets upregulated in GOF p53 mutants compared with the rest of the p53 mutants.
Experimental results using different datasets and several gene sets show that the proposal is able to outperform classical alternatives by using existing prior knowledge adapted from publicly available databases.
Several gene sets were over-represented in the α9−/− mice at both P13 and P60.
Computational analyses have highlighted differential expression of several gene sets upon loss of nicotinic cholinergic activity in the cochlea.
Several gene sets for prediction of breast cancer survival have been derived from whole-genome mRNA expression profiles.
Several gene sets associated with the cell cycle were enriched in ER− tumors, supporting the results from the functional annotation using DAVID (Text S2.B).
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Fungal pathogens upregulated several gene set categories involved in both primary and secondary metabolism including amino acids (glutamate, aromatic ones), flavonoids and isoprenoid mevalonate pathway.
In following sections we describe several gene set approaches for testing the null hypothesis H0SC (expression levels of all genes in a gene set are not associated with the phenotype) that use p-values from separate tests of association of the phenotype with the expression of each gene in the gene set.
Given that complex regulatory networks in stem cells can be best detected by expression analysis of many genes, we performed several gene set comparison analyses comparing our acquired resistance signatures with published ES cell signatures as reported by Ben-Porath et al13 (Table S6).
Several gene set analysis methods have been recently developed, both in the univariate and multivariate context.
Several gene set level summary statistics have been proposed in previous research on gene set testing (Ackermann and Strimmer, 2009; Jiang and Gentleman, 2007).
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