Previously, Alexander Varshavsky suggested the construction of a new kind of toxins referred as "sitoxins", a concept that artificially combines several functional protein domains to produce a therapeutically effective molecule.
Furthermore, several functional heterologous proteins, including lysostaphin [20], bovine casein [21] and hLF [22], have been produced via cattle mammary bioreactors.
At the other time points, several functional groups, including protein-protein interaction and stress response, were also enriched, with scores less than 0.01 (data not shown).
We propose that the six clades of GFP-like proteins may represent several functional classes of proteins with multiple variants in each class.
STRING visualized several functional clusters for proteins that were found to be elevated in ccRCC (Fig. 4), including ribosomal and proteasomal proteins as well as proteins involved in glycolysis and energy metabolism.
We focused on several functional classes of proteins that are known to affect host immune response.
Figure 1 also shows that the highly connected PCD-related proteins (i.e., proteins involved in several functional interactions) are typically more disordered than proteins with a lesser number of interaction partners.
Plasma proteomic profiles differentiating these three study groups comprised several functional categories including structural proteins, protease inhibitors, immune response-related (predominantly components of complement pathways), transporters, acute phase reactants, catalytic, coagulation and transcriptional factors (Table 1).
These include both cytoplasmic and membrane-bound proteins that can be grouped into several functional categories, such as cytoskeletal proteins, annexins, glycolytic enzymes, and tetraspanins.
Nucleolin protein contains several functional domains that mediate its functions [29].
