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However, relatively few active TEs have been identified and several expression studies indicate that transcription and transposition are rare for most elements [ 12].
Due to the importance of the IGVH status in disease course determination, several expression studies have focused on comparisons of the mutated IGVH vs. unmutated IGVH CLL forms [ 7– 9].
Several expression studies have been performed in an attempt to identify genes that could characterize subtypes of human melanomas, as well as to define verifiable gene signature profiles with predictive value for metastasis, clinical outcome, or survival [ 9- 19].
To address the question of developmental regulation of gene expression on a larger scale, several expression studies have been performed with the ascomycetes Gibberella zeae (anamorph Fusarium graminearum), Neurospora crassa, and Sordaria macrospora, all of which belong to the Sordariomycetes and form flask-like fruiting bodies called perithecia.
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Children successfully used a process of elimination to match a single expression to one of several labels (Study 1) and to match a single label to one of several expressions (Study 2).
Furthermore, several expression profiling studies in PBMCs showed a highly expression of S100A8, S100A9 and S100A12 in RA patients compared to controls [8], [38], [39].
Finally, a recent meta-analysis of several expression profiling studies revealed a ∼10% decrease (P = 0.019) of RTN4R transcript levels in brains of individuals with schizophrenia (www.stanleygenomics.org).org
Several expression profile studies in Arabidopsis have established that large scale changes occur in gene expression during cold acclimation and subsequent freezing tolerance [ 25- 27].
In the context of breast cancer, several expression profiling studies have provided preliminary evidence for the existence of therapy-predictive signatures.
Using a compendium of several expression array studies, we scored human breast tumors based on the manifestation of the JQ1 gene signature.
These genes were observed to be upregulated upon exposure to pathogens in several expression profiling studies [ 14, 15] suggesting a role in immune response.
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