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We found several existing tools that offered partial solutions, see Table 1.
Several existing tools use resampling based approaches [ 2, 16- 19], either permuting sample labels relative to gene expression, or performing bootstrap resampling [ 24].
GETPrime combines several existing tools: the PerlPrimer program (13), Blast (11) and the Ensembl database through a custom perl wrapper, which enables automation of the workflow and decision process for selecting the best primer pairs (see workflow, Figure 1).
We compared CTF with several existing tools as well as the PWM baseline method on a dataset generated by ChIP-seq experiments (TFBSs of 13 transcription factors in mouse genome).
Several existing tools (reviewed in [2]) support the interpretation of the complex dependence between the viral genotype and its drug susceptibility profile in vitro and in vivo.
Although there are several existing tools for visualizing and analyzing colocalization, either they are difficult to use for experimental researchers, not well maintained, or without measurements for colocalization strength.
Similar(53)
Thus, several of the existing tools that allow calculation of CAI are not web-servers; other require some kind of installation or execution; and some of them provide easy calculations that lack in flexibility.
IUTA has several advantages over existing tools: first, IUTA directly incorporates the uncertainty of the underlying DNA fragments corresponding to the paired-end reads into the RNA-Seq data model when estimating the isoform usage.
In order to perform NGS analysis steps, GensearchNGS includes several existing external tools through plugins.
Finally, we compare several existing conversion tools for KEGG pathways and show that the conversion from KEGG to BioPAX does not involve a loss of information, whilst lossless translations to SBML can only be performed using SBML Level 3, including its recently proposed qualitative models and groups extension packages.
The proposed stabilization method generalizes existing tools in several directions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com