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Several essential cellular functions of mitochondria depend on a high degree of functional interaction between the nuclear and mitochondrial genomes.
However, miRNAs have the ability to up-regulate or down-regulate several essential cellular enzymes and push the cell into cycle.
SUMO-1 is a ubiquitin-like modifier that regulates several essential cellular processes, i.e. nuclear-cytoplasmic signaling and transport, and regulation of gene expression [18].
This suggests that O-GlcNAcylation has been adopted to participate in one or several essential cellular processes in more complex eukaryotes.
The ATP-binding cassette protein RLI1 (yeast: [SGD YDR091C]) is a conserved factor that has been implicated in several essential cellular processes such as translational initiation [ 32, 33] and translational termination and recycling [ 34].
The nutrient-sensing target of rapamycin (Tor) pathway is highly conserved among eukaryotes and governs several essential cellular processes including protein synthesis, ribosome biogenesis, autophagy, and cytoskeletal organization [ 1- 3].
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Oncogenic transformation of a normal cell is a multistep process that requires activation or inactivation, usually by mutagenic events, of several key genes controlling various essential cellular pathways that are involved in growth and development.
Transcriptionally quiescent spermatozoa have been established to be a repository of mRNA coding for several functionally essential cellular proteins.
The results of the gene expression profiles in this group clearly represent the whole organism trade-offs that are occurring within the fish for several competing essential cellular processes.
The number of DIV required for the elaboration of all differentiated progeny was determined to satisfy several essential developmental and cellular criteria, including homogeneity of the developmental lineage species examined (>95%) and the absence of alternative neural species.
Because mitochondria serve several prominent and essential cellular functions such as energy homeostasis, signaling and apoptosis, it is reasonable to surmise that alterations in mitochondrial function could affect immune function.
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