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Interestingly, the assay performed in the present study uses xMAP technology to quantify several epitopes and thus several different Aß species.
To do this, drugs must exist in a multivalent form expressing several epitopes and likely therefore bound to a peptide or protein molecule.
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In FIV Fca, this region has been shown to contain the CXCR4 binding site [ 40], neutralizing antibody binding sites [ 41- 43] and several epitopes important for cell tropism and cell line adaptation [ 44- 46].
In addition, MPO-ANCAs of individuals have recognition properties with several epitopes of MPO and also different affinities for MPO [ 18, 19].
Lipopeptides TT Nef and TT Pol1, which contain several epitopes unlike lipopeptides TT Gag and TT Pol2, were able to induce most IFNγ-secreting CD8+ T-cell responses.
In addition to its role in cell wall biosynthesis, it has also been shown to be highly immuno-dominant in nature, with several epitopes recognized by CD4 and CD8 T cells [20], [21], [22].
HCMVpp65 is a strong T-cell antigen to most human and several epitopes within this antigen have been mapped from normal population [ 14, 26].
The third was the presence of several epitopes with overlapping B- and T-cell functions, wherein changes in sequence could cause possible deleterious effects on protective immunity in both the cell-mediated and humoral arms of the host immune response.
Several epitopes were first predicted by BCPREDS and BepiPred, but only those epitopes that were fully or mostly overlapped with the Disco Tope and ElliPro prediction were chosen as the final epitope candidates.
However, among the EBV antigens several epitopes of the latent protein EBNA1 and the immediate early lytic peptide BZLF1 are rather promiscuous in the MHC class I and II context [ 40].
Efficient variant-specific CTL responses to several epitopes restricted by HLA-A2, HLA-B8, and HLA-B15 in our study indicate that some very common epitope sequences previously have been adapted by a potent CTL response.
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