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After induction, isolated CD31+ cells expressed several endothelial cell marker genes and exhibited the ability to form vascular network structures similar to CD31+ cells from neonatal mouse heart.
The endometrial SP (ESP) cells exhibited preferential expression of several endothelial cell markers compared to endometrial main population (EMP) cells.
Moreover, we show that low-dose IR induces a rapid phosphorylation of several endothelial cell proteins, including the Vascular Endothelial Growth Factor (VEGF) Receptor-2 and induces VEGF production in hypoxia mimicking conditions.
HB-19 inhibits colony formation in soft agar of various tumor cells lines and impairs several endothelial cell functions involved in angiogenesis, such as cell proliferation and migration, tubule network formation, and neovascularization.
This response was observed in experiments with several endothelial cell types and was completely prevented by the presence of Hp.
Several endothelial cell line libraries used in this study contained less than 1000 sequences and comparisons between more than two libraries were required.
Similar(51)
To date, no endothelium-specific integrins have been discovered, but there are several endothelial-cell integrins that show a limited tissue distribution and, more importantly, are not expressed on quiescent endothelium but are upregulated in response to the tumor microenvironment.
Angiogenesis is characterized by several distinct endothelial cell activities including endothelial cell proliferation, invasion through vascular basement membranes and sprouting from quiescent monolayers [17].
Our survey of several primary endothelial cells including, HUVEC, HMVE and BAEC cells showed that c-Src is ubiquitously tyrosine phosphorylated in response to VEGF stimulation (Figure 1A) and associates with VEGFR-2 in a ligand-dependent manner in these primary endothelial cells (Figure 1C).
In a subset of GBM tissues, we found that several tumor endothelial cells carry EGFR amplification, characteristic of GBM tumor cells.
In several distinct endothelial cells investigated, serum proteins help Opc targeting of apical integrins (C. Sa E Cunha, N.J. Griffiths and M. Virji, in preparation; Virji et al., 1994; 1995; Unkmeir et al., 2002).
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