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When bound to GDP, RABs are inactive, but when bound to GTP, they become activated and interact with several effector proteins (Ung et al. 2013), including SNAREs, during the tethering of cargo at post-Golgi compartments (Cai et al. 2007).
Pathogenic yersiniae inject several effector proteins (Yops) into host cells, which subverts immune functions and enables the bacteria to survive within the host organism.
The genes that encode the secretion system, translocator proteins, several effector proteins and intimin are located in the bacterial locus of enterocyte effacement (LEE) pathogenicity island [16].
Several effector proteins of S. Typhimurium such as AvrA are highly homologous to effector proteins from phytopathogens, anticipating that some of the host-pathogen interactions might also be evident in the interactions with plants [36].
After DNA double strand breaks, the ATM-mediated DNA damage checkpoint pathway is activated by autophosphorylation and activation of ATM, which in turn, phosphorylates Chk2 that often initiates the phosphorylation of several effector proteins, including phosphatases of the cdc25 family or BRCA1 [25], [25].
Several effector proteins secreted by the Dot/Icm secretion systems have been identified.
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SIRT1 deacetylates several downstream effector proteins including KU70, NBS1, the FOXO transcription factor family, and p53, several of which are in response to DNA damage events occurring within the cell [ 1].
Several bacterial effector proteins delivered to host cells by the type III secretion system (TTSS) have been shown to suppress PTI [8], [9].
Using site directed mutants lacking several T1 effector proteins and flagellin expression, we found that SopE elicits caspase-1 activation even when flagellins are absent.
Several RhoA effector proteins have been implicated in the formation of these structures, including ROCK and mDia1 [ 55, 56].
Several LysM effector proteins were already shown to be involved in the dampening of host responses of plants against pathogenic fungi and their protection against chitinases.
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