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Furthermore, each major cnidarian lineage experienced specific duplications: group C HOX9-14 genes were independently duplicated in the Scyphozoa and in the Hydrozoa, and several duplications increased the number of HOX2 genes in the Anthozoa (figure 1).
Several duplications appear to be human specific, including a ∼400-kb duplication (99.4%99.8%% sequence identity) that transposed from chromosome 14 to the most proximal pericentromeric region of chromosome 22.
We describe a fifth exon and show that the locus has a complex evolutionary history with several duplications, pseudogenisations and losses of exons.
In addition, several duplications (Figure S2 and Figure 6) are predicted within individual supergroups as follows: A common ancestor to H. sapiens and D. rerio duplicated IPO8 (Figure S2(a)).
Instead, several duplications of the KLK1 gene occurred later in the evolution yielding 13 KLK1 homologues in the mouse genome and 9 KLK1 homologues in the rat genome (Figure 4).
Second, we identify several duplications that also suppress rol-3 –associated lethality.
Similar(30)
A portion of the duplicated sets combined several duplication types (e.g., duplicate set members present in both tandem and inter-chromosomal arrangements; Table 1).
Our findings are also in line with previous studies [ 7] where several duplication mechanisms were ranked by their potential of introducing functionally divergent duplicates in Arabidopsis.
In humans, these PYD-NACHT containing proteins have been expanded by several duplication events.
These data support our phylogenetic tree comparing all species, and show that several duplication events happened after the monocot-eudicot split and that many of them are species-specific as expected.
These observations suggest that this family experienced several duplication events prior to the origin of mammals.
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