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Increased resistance due to frequent or excessive use of systemic antimicrobials has been documented for several drug classes.
A correlation study for several drug classes performed in two laboratories with 32 clinical and 12 spiked drug free (controls) hair samples shows that implementation of the method on clinical chemistry analyzers is easy and that results obtained by different operators and instruments are comparable and reproducible.
The authors identified drugs most likely to be purchased by American consumers in several drug classes by cross-tabulating consumer self-reports [7] with industry data, including lists of the most-popular online drug searches from licit website pharmacies and IMS's list of the top 10 products "most often prescribed" in the United States in 2007.
Several drug classes have relevant venodilating potential, including ACE inhibitors, ARBs, and nitrates.
Generally, these mutations were costly, although several drug classes and species of bacteria on average did not show a cost.
Despite positive findings with several drug classes, the very heterogeneous nature of PHN makes successful pain management difficult.
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Interestingly, autoimmune and pancreatic disorders are disease classes with connections to several drug MoA classes, reflecting the multiplicity of molecular mechanisms affecting these disorders.
Over the past decade, several antihyperglycaemic drug classes have been introduced into the market.
Statins are the agents best studied, but several other drug classes might also have clinical utility [ 13, 14].
In addition, several major drug classes [e.g., selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotics] represent novel compounds (new molecular entities) introduced, implying that much less information is known about their safety profile at the time of marketing [ 30].
Breast cancer is recognized as a heterogeneous disease and response to treatment seems to depend on molecular characteristics of the tumor, some of which confer resistance to specific drugs while others confer a more multiresistant phenotype covering several different drug classes [ 2- 8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com