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The xylose fermentation ability and redox balance of the recombinant strains were improved significantly by over-expression of several downstream genes.
Additionally, we found that myricetin activated the Wnt/β-catenin pathway and increased the expression of several downstream genes including T-cell factor-1 TCF-1) and lymphoid enhancer factor-1 TCF-11).
Overexpression of OsWRKY30 enhanced resistance to R. solani and M. oryzae possibly by activating several downstream genes, including JA biosynthesis-related genes (Peng et al. 2012).
With this approach, several downstream genes of signaling pathways involved in controlling mouse pancreas development have been reported [49], [50].
By affecting miRNA target function, miR-polymorphisms can potentially affect the expression of several downstream genes and related pathways in a cell [36].
We then examined the expression of several downstream genes, IL-6, IL8, p50, and COX-2.
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Several downstream gene targets important for adipocyte differentiation also have reduced expression, suggesting that ATF4 affects lipid accumulation by promoting adipogenesis.
Previous work revealed that these NAC domain TFs can directly activate the expression of secondary wall-specific biosynthetic genes and activate the expression of several downstream transcription factor genes that also directly regulate genes involved in the biosynthesis of secondary wall components [ 55, 58].
The GAS Mga locus contains several downstream virulence genes regulated by Mga, including genes encoding M-proteins and C5a peptidase.
Several downstream target genes of the AKT and p53 pathways were also upregulated in T1D subjects, relative to controls.
The master regulator p53 tumor-suppressor protein through coordination of several downstream target genes and upstream transcription factors controls many pathways important for tumor suppression.
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