Sentence examples for several downstream effectors from inspiring English sources

(e) PTH binding activates PTH1R to stimulate several downstream effectors.

Our deterministic model offers insight into stimulus-response relationships between Epo and several downstream effectors.

ABSTRACT A core set of autophagy proteins is required for gamma interferon (IFN-γ -mediated clearance of Toxoplasma gondIFN-γ -mediated because of theIFN-γ -mediatedeveral downstream effeclearancecluding immunity-related GTPases (IRGs) and guanylate-binding profeins (GBPs).

Several downstream effectors which are directly or indirectly regulated by 3-phosphoinositides and are involved in chemotaxis have been identified [3], [4].

Mismatch recognition by MutS homologs (MSH) results in long-lived ATP-bound sliding clamps that recruit MLH/PMS, which in turn stimulate the DNA transaction activities of several downstream effectors.

PLCγ1 hydrolyzes phosphatidylinositol-4,5-bisphosphate to generate the second messengers inositol-1,4,5-trisphosphate and diacylglycerol which in turn can activate several downstream effectors including specific protein kinase C (PKC) isoforms leading to many cellular responses [18].

SIRT1 deacetylates several downstream effector proteins including KU70, NBS1, the FOXO transcription factor family, and p53, several of which are in response to DNA damage events occurring within the cell [ 1].

ALK can be detected as a fusion protein kinase or full-length receptor protein in several tumour types (Kelleher and McDermott, 2010), and in both cases it drives tumour biology through phosphorylation and activation of several downstream effector proteins.

Activation of the Nrf2 pathway and up regulation of several downstream effector proteins has also been reported specifically due to cigarette smoking on resident macrophages, lung bronchial and alveolar epithelium and lung fibroblasts of chronic smokers [ 93].

However, several putative downstream effectors of Fbxo32 were regulated similarly to other cases of muscular atrophy.

As hyper-activation of several EGFR downstream effectors, including RAS and STAT3, elicits increased DNA damage accumulation [9], [10], [11], we tested whether the expression of a clinically pertinent EGFR oncogene, EGFRvIII [6], caused increased requirement for DNA repair as a form of non-oncogene addiction.