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Using these data in blood concentrations and MICs, the probabilities of attaining various percentages of the dosing interval during which drug concentrations remain above MIC (T > MIC) were calculated at several dosing regimens.
We studied several dosing regimens of cefazolin in humans to determine safety and whether or not adequate serum and tissue antibiotic concentrations could be achieved in patients undergoing cardiac bypass.
Several dosing regimens of indomethacin have been used for prophylaxis and treatment of PDA [ 123].
Several dosing regimens were compared over a 12-week period: 100mg solanezumab every 4 weeks, 100mg weekly, 400mg every 4 weeks, 400 mg weekly.
To our knowledge, this is the first study that compared carbetocin with oxytocin in several dosing regimens used in the Netherlands for the prevention of uterine atony.
The aim of the study was to compare the prophylactic effects of carbetocin with those of oxytocin in several dosing regimens for the prevention of uterine atony in patients undergoing elective CS under regional anaesthesia in the Netherlands.
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Paliperidone palmitate has been studied in several randomized, double-blind controlled trials using various dosing regimens [ 9- 14].
Patients were treated with fluoxetine or placebo for three cycles, with the use of several different dosing regimens, followed by single blind placebo treatment for one cycle.
A definitive conclusion might be achieved by a more extensive dose fractionation study up to 48 h with several different dosing regimens to break the colinearity (44 – 44).
Although several different dosing regimens of Gem+Dox were applied in previous studies, they were all similar in that gemcitabine and doxorubicin were both given on day 1 and, in some cases, were given together again on day 8 (Pérez-Manga et al, 2000; Gomez et al, 2001; El Serafy et al, 2003; Bensalem and Bouzid, 2006).
Several studies have examined optimal dosing regimens of taxanes.
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