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To determine whether levobupivacaine produces a more potent and longer lasting peripheral nerve block than ropivacaine, we compared functional blockade of sciatic nerve in the rat at several doses with these 2 agents.
Related gatekeeping procedures addressing the problem of comparing several doses with a control for multiple hierarchical endpoints were described, among others, by Dmitrienko et al. (2006), Liu and Hsu (2009), and Xu et al. (2009).
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These included increased community involvement and the effective use of monovalent vaccines to immunize children in insecure areas with several doses, within a short period of time.
The reaction may not be of the same severity with successive exposures, but it can occur for the first time after several doses or with a slow infusion [ 4].
Each bin may include several doses each with a reference to a certain medication index to avoid duplicate medication information.
For example, Astrup et al. (10) described the impact of treatment with several doses of liraglutide compared with placebo and orlistat in obese individuals without diabetes.
Pretreatment of cells with several doses of oridonin for 24 hr and further cotreatment with As III) for an additional 24 hr resulted in a significant reduction of ROS levels, especially with 5.6 μM oridonin.
Pre-treatment with several doses of apocynin (0.05, 0.1 and 1.0 mg/kg) in combination with a single dose of lipoic acid (0.005 mg/kg) resulted in a dose-dependent reduction in infarct volume up to ∼50%.
Even though this dose elicited clinically and statistically significant improvements, an experimental design with several doses (including lower doses for some genotypes) and longer periods of treatment with MPH treatment will be important to further explore the clinical implications of the present findings.
He's a regular guy with a history of opiate use, who carries a kit with several doses of naloxone, a life-saving opiate blocker also known by the trade name Narcan.
In this scenario, an intervention is used to treat mice challenged with several doses of LPS.
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CEO of Professional Science Editing for Scientists @ prosciediting.com