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Schedules including several doses in early infancy provided little additional benefit over programs starting with 1 dose at the age of 12 months.
Two major side effects appeared to be drug‐related: One seizure occurred at 600 mg/day, and elevations of alkaline phosphatase were noted at several doses in six patients.
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In a previous article [ 26], we presented data obtained from a model of CDDP-resistant testicular GCT (TGT38R) generated in our laboratory after the administration of several doses of in vivo cisplatin.
Changes from baseline were observed for several doses and, in particular, the 100 mg dose for QTcF; however, the observed variability in all cohorts was considered normal physiologic variability and did not represent a clinically significant trend or abnormality.
Jonker et al (2011) in a study of brivanib, a dual VEGFR and FGFR tyrosine kinase inhibitor, investigators evaluated DCE-MRI responses in several dose schedules in selected patients known to respond to anti-VEGF therapies and then selected the optimal schedule for a phase II trial.
"Our opinion is that patients will need to have several doses of psychedelics in combination with treatment.
Examination of several doses of daptomycin in an experimental murine S. aureus thigh infection model demonstrated concentration-dependent bactericidal activity.
A recently released double-blind, randomized study evaluated several doses of vaccine in 210 individuals and also found lower seroconversion rates among patients with CD4 <350 cells/mm3 [ 22].
For example, the serum DCA levels after 5 years of continued treatment with oral DCA at 25 mg kg−1 are only slightly increased compared with the levels after the first several doses (and remain in the range of approximately 100 μg ml−1) (Mori et al, 2004).
It was tested for carcinogenicity by inhalation in one strain of mice at the maximum tolerated dose [ 38] and at several dose levels in a limited study in which treatment started in utero [ 31].
Also, we tested several doses of the extracts in three different solvents/ delivery systems in order to verify the best concentration of each system.
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CEO of Professional Science Editing for Scientists @ prosciediting.com