Regulation of transcription initiation is controlled by several distinct processes, including binding of transcription factors to distal and proximal binding sites and the accessibility of DNA [ 1- 3].
Recent studies from this laboratory have identified several distinct high-affinity lead-binding proteins (PbBP) from rat kidney and brain that appear to play critical roles in the intracellular bioavailability of lead to several essential cellular processes in these target tissues at low dose levels.
The different arrangements of these receptors in the plasma membrane reflects the fact that there are several distinct mechanisms by which sugar binding at the cell surface leads to events on the cytoplasmic side of the membrane.
Interestingly, a number of other histone demethylases encode potential DNA-binding domains, including several distinct classes of Zn-finger and ARID DNA-binding domains [ 35, 55].
Scheffers, D. J., Jones, L. J. & Errington, J. Several distinct localization patterns for penicillin-binding proteins in Bacillus subtilis.
Examples are the Tcf4 β-catenin binding domain and the WH2 binding domains of thymosin β4 or ciboulot, which have been shown to adopt several distinct conformations upon β-catenin and actin binding, respectively.
The gene cdkl3 appears to act as either a cell cycle mimic or regulator with several distinct functions including ATP & nucleotide binding, kinase activity, and transferase activity; all of which relate to regulation of the cell cycle and control of cellular proliferation.
The binding sites for several distinct P. falciparum strains were shown to be overlapping, but not identical (Refs 76, 77, 78).
Gel electrophoretic analysis of cross-linked samples showed that the longer TS1 33 construct formed a single defined complex with the hTS protein, while the TS1 14 oligonucleotide gave rise to several distinct complexes, likely because of multiple binding events of the smaller RNA.
The MHCI peptide-binding groove has several chemically distinct-binding pockets (termed A F) [ 7– 9].
