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During the branching morphogenesis program, the distal epithelial progenitors give rise to several differentiated epithelial cell types of the conducting airway [5].
Thus, the Sox17-induced bronchiolar-like structures contained a mixed population of cells that expressed CCSP, Foxj1, Sca-1, CCSP+/Sca-1+, and CCSP+/proSP-C+, consistent with reprogramming of progenitor cells along several differentiated pathways.
Therefore, we examined the pattern of 3p LOH among several differentiated portions within individuals.
Epigenetic changes across primary germ layers occurring in this period will result in levels common to several differentiated tissues [ 57].
The ability to control sophisticated gene expression patterns enabled these ancient organisms to evolve several differentiated forms, invade multiple hosts and evade host immunity.
In agreement with this view, genetic structure analyses of northern European populations have detected several differentiated clusters, which support multiple sources of postglacial colonization [ 18- 20].
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Although the proportion of affected genes in higher plants seems lower, based on published expression profile data, the actual number should be even higher than that in yeast, considering that higher plants are composed of several highly differentiated tissues and cells.
After several passages, differentiated cells and ES cells were infected with EF-1α recombinant MCMV at an MOI of 10 and incubated for 24 hr.
However, later on during differentiation, HLA class I expression may be down-regulated or lost as suggested by the finding of failure to constitutively express HLA class I in several terminally differentiated cell types like neurons, hepatocytes, skeletal and cardiac muscle cells [17].
The results indicate that for Malawi there were several geographically differentiated HIV/AIDS epidemics rather than a single one.
However, it is also possible that the lack of an expansion signal indicates there have been multiple introductions into Southeast Asia from several genetically differentiated sources.
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