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Lastly, our somewhat surprising observations that coilin overexpression can reduce the RNA levels of several different transcripts (Fig. 2) implies that coilin may serve as a transcriptional regulator for these genes and/or takes part in the degradation or processing of these RNAs.
However, as probes of a given probe set were allowed to match several different transcripts, their overall signal will still be influenced by several transcripts.
Other mutations lead to the use of a cryptic splice site (cases: 5, 6) or to several different transcripts with a combination of exon-skipping and the use of a cryptic splice site (cases: 1, 2, 16, 26, 54).
A gene may have several different transcripts, therefore several promoters.
BRCA1 is a very large gene that generates several different transcripts.
Most likely the deformation observed is a combination of altered levels of several different transcripts.
Similar(48)
Alternative splicing that can result in the generation of two to several different transcript isoforms is now known to be widespread.
As described in the text, both barley and maize genes showed several different transcript patterns.
Human ADAM12 mRNA is alternatively spliced, with several different transcript variants giving rise to distinct ADAM12 protein isoforms.
Real time PCR experiments were performed using a panel of different primer/probe sets to assess the expression of several different IGF2 transcripts and showed that both P1 and P2 P4 driven transcripts were expressed in all the four MSC populations (data not shown).
miRNA regulation can be highly pleiotropic, with one miRNA able to target several hundred different transcripts, and one mRNA able to be cooperatively targeted by several miRNAs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com