Atherosclerosis is a complex disease in which associated inflammation probably occurs through several different pathways, and this complexity presents an obstacle to successful clinical treatment.
Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection.
There exists several different pathways for loading antigenic peptides onto MHC class I molecules, either based on the endogenous cytosolic MHC I pathway or on cross-presentation.
This is still a fairly primitive use of the technology; once GEN has learned where students go wrong, it plans to videotape the professor offering a series of alternate explanations of the same material, so that a student can be directed along any one of several different pathways to help him or her grasp what wasn't clear the first time around.
At around 1 V vs. Pd/H2, initiated by a one-electron transfer, the oxidation of colchicine sets off leading to a cation radical, whose further oxidation may evolve on several different pathways.
Several different pathways, most notably the activation of inflammatory transcription factors and the induction of inflammatory genes and cytokines, may contribute to heart injury following renal IRI.
Thus, M1 phenotype exacerbates neuronal dysfunction by several different pathways, which include, at least, cytokine and ROS production and glutamate excitotoxicity [81, 88].
A growing body of evidence also suggests that sleep plays an important role in maintaining a healthy weight, via several different pathways.
However, we hypothesize that schools may influence students' asthma outcomes through several different pathways.
The complex changes in transcription seen in the differentiating ES cells analyzed here reflect the several different pathways that can control ES cell pluripotency and self-renewal.
For example, no genes known to influence serum UA levels were identified by recent GWA studies on CAD, but genetic loci involved in several different pathways were found [11], [12], [29] [32].
