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For the same reason, image-guided thermal ablations have been successfully applied in several different organs, including liver, lung, bone, and even neck tumours [5, 7, 8, 9, 10, 11, 12, 13, 14].
Two of the clusters included tumors from several different organs, revealing hidden similarities among seemingly distinct cancers.
AFP-producing tumors have been reported in several different organs [ 5- 7].
Both NO and CNP act as a biological messengers and endogenous vasodilators in several different organs [ 14].
HSA can occur in several different organs including the spleen, liver, heart, muscle, retroperitoneal space and subcutaneous tissues.
HACs have been described in several different organs, including the lung, pancreas, esophagus, ampulla of Vater, colon, urinary bladder, renal pelvis, ovaries, uterus, and cervix [ 2- 12].
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CCCs were defined based on Feudtner's list that incorporates any medical condition that can be reasonably expected to last at least 12 months (unless death intervenes) and to involve either several different organ systems or 1 organ system severely enough to require specialty pediatric care and probably some period of hospitalization in a tertiary care center [ 17].
Complex chronic conditions—We defined complex chronic conditions as respiratory, renal, gastrointestinal, metabolic, haematological, congenital or genetic defect, malignancy, and cardiovascular diagnoses expected to last longer than 12 months that involve either several different organ systems or one organ system severely enough to need specialty paediatric care and admission to hospital.
In 2000, Feudtner and colleagues developed a definition for CCCs: "Any medical condition that can be reasonably expected to last at least 12 months (unless death intervenes) and to involve either several different organ systems or 1 organ system severely enough to require specialty pediatric care and probably some period of hospitalization in a tertiary care center"[ 1].
The reported birth defects occurred in several different organ systems, including the musculoskeletal, cardiovascular and circulatory systems, with no pattern to the organ systems affected.
We have broadened the field, looking at several different organ systems and included diverse groups of hospital and emergency room patients.
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