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Although there are several crystal structures available, mostly of the class of aryl sulfatases, sequence and structural information are still scarce with regard to alkyl sulfatases.
Several crystal structures for FOXO transcription factor DBDs have been solved, and reveal that the structural basis for FOXO protein recognition of DNA comes from direct base-specific contacts as well as phosphate contacts between DNA molecules and critical C-terminal arginine/lysine amino acid residues in the FOXO DBD [29], [30].
Several crystal structures of the bacterial voltage-dependent Kchannel have provided intriguing insights into how voltage-dependent ion channels work.
In addition, the availability of several crystal structures for HCV RdRp paved the road for conducting rational-based drug design.
Several crystal structures of human CK2 have been published with different conformations for the CK2α catalytic subunit.
The employed PDB entries were the most suitable ones of several crystal structures available for protein kinase A because of their similarity to the compounds contained in MUV548.
The work is based on comparative studies of 157 ligand binding proteins, for which several crystal structures (in ligand-free and ligand-bound forms) are available.
The anion π anion binding mode observed for nitrate in compound 2 is also observed in several crystal structures involving cytosine ring coordinated to transition metals.
Several crystal structures of CK2 are available, many in complex with ATP-competitive inhibitors, showing the presence of regions with remarkable flexibility.
The conformational changes behind this mechanism have been characterised by several crystal structures of AT in the absence and in the presence of pentasaccharide.
The structural difference between tyrosinase and catechol oxidase as the basis for their catalytic activity is still a puzzle although several crystal structures of both enzymes exist.
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