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In addition, elucidation of the structural basis for several crucial functions of other viral proteins (specifically the non-structural NS1A protein, the nucleoprotein and the viral polymerase) has identified novel targets for the development of new antivirals.
Trees serve several crucial functions for the planet.
Thus, TERRA may mediate several crucial functions at the telomeres, a region of the genome that had been considered to be transcriptionally silent.
Lon is a highly conserved AAA+ (ATPases associated with a variety of cellular activities) protease and is committed to several crucial functions, including adenosine-5′-triphosphate (ATP -dependent proteolytic, DNATP -dependent chaproteolytic activity.
Emerging evidence suggests that TERRA plays important roles in the regulation of telomerase, maintaining higher-order telomeric chromatin structure and mediating several crucial functions of the telomeres [ 74, 77].
The nucleolus plays several crucial functions in the nucleus: in addition to its function as ribosome factory of the cells it is a multifunctional nuclear domain, and nucleolar activity is linked with several pathologies.
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TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy.
mTOR signaling complex affecting several crucial cellular functions, which show clear effects on ageing [ 24]. mTOR activity is linked to IIS pathway through multiple connections.
They include the direct cytopathogenic effects of the virus, that causes the destruction of infected cells, and indirect effects, that represent an amplifying mechanism leading to the destruction/impairment of several crucial body functions, as those played by the innate and adaptive immune system and by the endothelium.
A number of biochemical, genetic and molecular biology methods have been developed for H. volcanii [ 12, 13], and their successful employment has enabled the identification of key factors involved in several crucial cellular functions, including the components of the two predominant protein transport systems [ 14, 15] and the proteasome [ 16].
This assumption is supported by the recent identification of several novel crucial functions, i.e., non-metabolic activities that are required to cope with stress conditions other than oxidative stress, especially in plants.
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