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As can be seen in Figure 2, the amount of non-cancer tissue present within a tumour alters both the B allele and logR signals for several copy number changes.
These complex tumors showed several copy number alterations per sample, affecting almost all chromosomes.
aCGH analysis revealed several copy number changes in both cell lines.
However, the region between these sequences exhibits several copy number changes, inversions and deletions/insertions.
Genome-wide array-CGH analysis detected several copy number aberrations in 90.7% (59/65) of the cases (Supplementary Table 2).
Interestingly, K1 (GLAG-66) and B-CPAP share several copy number changes, whereas the TPC-1 profile is clearly different from these other two models.
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Although, the assembly algorithms tend to collapse the highly identical repetitive sequences into one copy, high coverage in that specific area might serve as a signature for identifying regions present in several copy numbers in the genome [ 52].
A sequence detection system (ABI PRISM 7900HT; Applied Biosystems) was used, and a calibration curve was created using several copy-number standards with plasmids containing the amplified mtDNA fragments (nucleotide position in mtDNA; 5205 5767) for either wild-type or mutant sequences.
Since high-copy-number sequences generally tend to have a heavier methylation state than low-copy-number sequences, we investigated the methylation state of ERTBVs in several Oryza species with various copy numbers.
Recent studies have revealed several recurrent copy number variations (CNVs) that are more likely to be associated with epilepsy.
Tumors of stage 4 contain several structural copy number aberrations (CNAs) rarely found in stage 4S.
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