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Alternatively, this region could be flexible and adopt several conformations at the virion surface, only some of which are recognized by specific neutralizing antibodies.
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Accordingly, we have used cryo-EM to determine the structures of several conformations of the CrPV-IRES/ribosome complex at resolutions beyond 4 Å, which allowed us to build and refine complete atomic models for the complex.
Unlike cyclohexane, in which one conformation (the chair) is much more stable than any other, cycloalkanes with 7 12 carbons are generally populated by several conformations of similar energy.
Peptides in solution currently exist under several conformations; an equilibrium which varies with solvent polarity.
A comparison of the structures suggests that the conformation of the N-terminal segment is not highly restricted in the complex and may adopt several conformations.
Similarly, the vacuolar SNAREs may associate in several conformations when pairing in trans.
The available A3A NMR structure shows that the conformation of loop-1 differs from that of other known APOBECs and is very flexible in adopting several conformations [ 47].
constructed several structural signatures corresponding to the different ligand/ligand binding site conformations at a predefined specific level of the hierarchical tree.
A phosphorylation site mutant of OmpR reveals different binding conformations at ompF and ompC.
Prion-like proteins have the capacity to adopt multiple stable conformations, at least one of which can recruit proteins from the native conformation into the alternative fold.
However they have different conformations at the N-terminal.
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