Sentence examples for several conformational changes from inspiring English sources

Bax-α exists in inactive form and several conformational changes are required during apoptosis to activate it.

Once the MEK inhibitor binds the pocket, several conformational changes follow, causing MEK1 and MEK2 to be locked into a catalytically inactive state.

During the eukaryotic cell cycle, chromatin undergoes several conformational changes, which are believed to play key roles in gene expression regulation during interphase, and in genome replication and division during mitosis.

This compound binds to MEK1/2 and induces several conformational changes in the unphosphorylated MEK1/2 enzymes, inhibiting their catalytic activity, which results in an inhibition of ERK activation and a blockade of the signal transduction pathways.

The structural analyses show that these TetR proteins recognize their inducer with an extensive multidrug-binding pocket and several conformational changes of the binding pockct-related parts [5], [6], [11].

All simulations were run for 1500 ns, which allows for several conformational changes.

Another study revealed several conformational change steps during nucleotide incorporation by Dpo4 by monitoring fluorescence from Trp introduced at residues distant from the active site.

It was found that TEIIs can have several conformations, and their conformational changes enable interactions with multienzyme domains.

Many enzyme reactions involve several chemical and conformational changes [29, 30], and the chemical step(s) may not always be rate limiting.

HPV's cycle of replication starts with adsorption to cells followed by a lag (several hours) where conformational changes mediated by host factors increase L2 N-terminus exposure.

The fidelity of correct nucleotide incorporation into damaged DNA is essential for Pol β repair function, and several studies have implicated conformational changes in Pol β as a determinant of this repair fidelity.