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Several complex diseases have been mapped and fine mapping is underway.
The diffusion of exome sequencing technology provided evidence for the role of rare coding variants in the aetiology of several complex diseases, and a cost effective alternative to exome sequencing is provided by the recent development of "exome" genotyping arrays, which were created to genotype rare coding variants identified by exome sequencing of thousands of individuals [28].
With emergences of new paradigms in multi-target drug discovery for several complex diseases, multi-target virtual screening has been presented and executed to discover the regimen which could target many different proteins and could be of low cost, efficacy and better tolerance.
Various extensions have been suggested, and, in this report, we compare their accuracy by applying them to several complex diseases.
In this review, we summarize the network approaches used to study ABCC6 and the role of this gene in several complex diseases.
Single-nucleotide polymorphisms (SNPs -based genome-wide aSNPs -basedstudies (GWAS) have identified low-risk conferring common variassociationeral complex distudies
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Common CNVs have been reported to be associated with several complex disease phenotypes including HIV acquisition and progression [31] [33].
From 2006 to 2008, several dozen large-scale genome-wide association studies were published tackling various complex diseases [7].
Recently, genome-wide association (GWA) studies have successfully contributed to the gene discovery process by identifying common genetic variants in several complex human diseases including NAFLD.
CNVs have been associated with several complex human diseases (Girirajan et al. 2011).
The ICOS B7h interaction has also been shown to influence the outcome of pathogenesis in several complex autoimmune diseases, transplants, allergy, and tumor models [ 12, 13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com