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The metabolism of glucose was examined in several clinical isolates of Neisseria gonorrhoeae.
For the NP therapies, the results indicates, microtiter plate assay method is an accurate and reproducible method for antibiofilm screening, and assay serves as a reliable quantitative tool for determining the antibiofilm potential of nanoparticles in combination with antibiotic agents against several clinical isolates.
To detect the relBE2Spn mRNA in several clinical isolates, primer extension analyses were carried out.
We have separately shown that the PrrH RNA is synthesized by other P. aeruginosa strains that share this genetic structure, including several clinical isolates (unpublished data).
With the availability of whole genome sequences of several clinical isolates [2], [3], [4], the genetic diversity of M. tuberculosis has been chronicled in the form of insertions, deletions, and single nucleotide polymorphisms (SNP).
To investigate the causes and evolution of drug-resistance, we determined the DNA sequences of several clinical isolates - one drug-susceptible, one multi-drug resistant, and nine extensively drug-resistant - using whole-genome sequencing.
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In this study, we report the in vitro antimycobacterial activity of UA and OA isolated from the hexanic extract of the aerial parts of C. tepejilote and L. hispida, against the reference drug-sensitive M. tuberculosis strain H37Rv, monoresistant H37Rv strains, several MDR clinical isolates and a group of nontuberculous mycobacteria.
The results presented here confirm and extend these studies, showing that purified UA and OA have in vitro antimycobacterial activity against fully drug-sensitive and monoresistant H37Rv strains, as well as several MDR clinical isolates and to a lesser degree, non-tuberculous mycobacteria.
These results conflict with the high rate of NS3 gene mutation reported in a recent study of the full-genomic sequences of several DEN-3 clinical isolates [32].
A previous study found a positive correlation between the level of gliotoxin production in several A. fumigatus clinical isolates and their pathogenicity level in greater wax moths [12].
Determination of the nucleotide sequence of several of the clinical isolates belonging to the three pneumococcal relBE Types (Table S1) showed no sequence changes in the antitoxin-encoding relB2Spn gene.
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