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Interestingly, several cellular process and metabolic pathways were also differentially regulated, including cell cycle (53 genes), apoptosis (35 genes), and ubiquitin-mediated proteolysis (51 genes), suggesting some underlying phenotypic differences between CMCs and PBMCs that may not be explained solely by makeup of the cell population.
The TPR is one of many repeat motifs that form structural domain mediating protein-protein interactions in several cellular process including translocation and degradations of proteins [ 68, 69].
The Archaea had VPI scores less than 0.15 for several cellular process categories including cell cycle, cell wall biosynthesis, motility (VPI = 0), and trafficking; outside this group, translation and unassigned functions also had VPI scores less than 0.15.
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Ribonucleoprotein (RNP) complexes are involved in several cellular processes, including RNA processing, transcription and translation.
Spastin (SPAST/SPG4) is a microtubule-severing protein, which links cytoskeletal dynamics to membrane remodeling in several cellular processes.
FoxO1 regulates several cellular processes including cellular differentiation, growth, survival, metabolism, stress response, DNA repair and cell death17,18,19,20,21.
RAS signaling affects several cellular processes in PDAC, including cellular proliferation, migration, cellular metabolism and autophagy.
Several cellular processes rely on the fine tuning of actin cytoskeleton.
It alters the functional proteins or recruits other proteins by providing a scaffold on the modified proteins and thus regulates several cellular processes.
Armadillo repeat proteins are abundant eukaryotic proteins involved in several cellular processes, including signaling, transport, and cytoskeletal regulation.
The description of these networks with mathematical models requires the definition of functional units that group together several cellular processes.
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