PLAB apoptotic-inducing activity has been observed and reported by other authors in several cellular contexts and following treatment with different anticancer agents [9], [18]-[21].
Moreover, of several cellular contexts tested (DA/DB motor neurons, amphid neurons, and phasmid neurons), only in DA/DB motor neurons did the hst-3.1 ; hst-3.2 double-mutant display a moderate enhancement compared to the single mutants.
48 Indeed, several regulatory mechanisms for LGR5 expression have been identified in various cellular contexts.
As RhoA is known be a PKA-signalling effector in a plethora of cell responses [11], [58], [44] and to play an important role in regulating p38 kinase activity in several cellular regulatory contexts [11], [32], [63], [64], we analysed its involvement in underlying the down-regulation of p38 by PKA and in their regulation of E7-dependent activation of NHE1.
HGF interacts and activates MET receptor (Bottaro et al., 1991) to induce context-dependent several cellular processes such as proliferation, cell movement or morphogenic differentiation (Brinkmann et al., 1995; Clague, 2011; Jeffers et al., 1996; Medico et al., 1996).
Regarding MAPK signaling, it was also striking to observe the downregulation of several GE Fs such as RasGrf2, Sos1, RasGRP1 and RasGRP2, known for their ability to activate various Ras family members in different cellular contexts.
Furthermore, our EGFR signaling model based on the HFPNe architecture enabled reduction of the factors responsible for mutational effect to several alterations in the reaction parameters with consideration for different cellular contexts.
In addition to these core components of the Notch pathway, several other proteins are used to regulate Notch signalling in some cellular contexts, and act either on the receptor Notch or on the ligand DSL.
There is also an increasing awareness that signaling pathways function across several cellular compartments and so their operation must be understood in this context.
In addition, it has been showed that several profibrotic genes, such as fibronectin, collagens, and OPN, are β-catenin target genes in different cellular contexts [ 17– 17].
There is convergent evidence from several sources that the expression of Plxdc2 may be dynamically regulated in response to cellular stresses or in unusual cellular contexts, including cancer.
