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Over the course of these titration studies it was observed that even in the absence of the inducing ligand some cytotoxicity and/or gene expression could be seen in several cell systems, including DT40 B lymphocytes [11], [19], [26], [27].
Our data are in agreement with previous studies where several cell systems have been shown to respond differently to Ca2+ or NPS R-467 treatments in relation to their effects on cell proliferation which can be stimulated or inhibited to a different extent [32], [44] [46].
BA is known to induce apoptosis independently from p53 in several cell systems.
The whole genome DNA-binding profile for CTCF has been elucidated in several cell systems (see, for example, [ 6- 9]).
A strong regulation of the IL-8 gene by HDAC inhibitors has been reported in several cell systems.
This form was used to deliver siRNA or oligonucleotide and the effectiveness was proven in several cell systems [ 12, 15].
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Several studies have identified in various cell systems, such as monocytes/macrophages and endothelial cells, specific cellular receptors (RAGE) that bind AGE proteins.
Several cell culture systems and animal models designed to empirically evaluate the safety of vector systems are being developed and should provide useful data for weighing the relative risks and benefits for specific diseases and patient populations.
This lack of ability to bind heparin sulphated proteoglycans in the ECM may be the reason why FLRG is less effective than follistatin at inhibiting activin A bioactivity in several cell culture systems [ 24].
Given the lack of effective therapy for AIPC, selenite, an inorganic form of selenium, is of particular significance because administration of selenite exerts strong anticarcinogenic effects by increasing ROS levels in several cell culture systems and animal models.
In vitro studies in several cell culture systems have shown that HIF is activated at approximately 5% O2 (40 mmHg) and activity increases with decreasing oxygenation down to 0.2-1.0 0.2-1.0.8 mmHg) O2 nearing anoxia [ 12].
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