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The predicted binding affinity of identified inhibitor is higher than available inhibitors with a 100-fold selectivity towards Plk1 over Plk2-4 and several cell cycle kinases.
Western blotting was used to analyze the expression of several cell cycle regulators in aortic EC.
NF-Y supports basal transcription of several cell cycle regulatory genes, e. g.
Thus, we have provided evidence that several cell cycle regulators are impacted by the maintained expression of Hnf6.
Among the PSC-related genes that were up-regulated in tumors are several cell cycle genes (e.g., Mcm2, Cdc6, and Pole).
Protein levels for several cell cycle regulated proteins were examined by Western blot at 3, 6, 9, and 12 hrs after release (Fig. 4C).
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Rosiglitazone caused endothelial arrest at G1 phase via affecting several cell cycle-related proteins that led to attenuate phosphorylation of retinoblastoma protein.
To address the possible pathway involved, expressions of several cell cycle-related genes, including Rb, Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, p27kip1, and p53 were compared between wildtype and CHD1L-transgenic MEFs.
Skp2 has been shown to regulate cellular proliferation by targeting several cell cycle-regulated proteins for ubiquitination and degradation.
It can regulate several cell cycle-related genes, including cyclin D1, cyclin E, p21, p27 and BRCA1 (11, 18).
Several cell cycle-specific nuclear antigens have been recognized with various immunohistochemical methods, allowing a reliable evaluation of tumor growth fraction.
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