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The scar-treating compound was designed to reduce the expression of a protein called connective tissue growth factor, or CTGF, which regulates several biological pathways involved in wound healing and scar formation.
Several biological pathways (including neuroplasticity, inflammation, circadian systems, and HPA axis) are likely to play a role in the long-lasting consequences of childhood trauma on the risk for (severe) BD, in addition to the high level of somatic comorbidities.
These proteins are associated with several biological pathways including oxidative phosphorylation, cytoskeleton maintenance, calcium homeostasis, chaperoning, synaptic plasticity and neurotransmission.
It is noteworthy that this phenotype is manifest at both levels of gene regulation examined as well as in several biological pathways.
Therefore, discovering the mechanisms of HIPK2 inhibition and the ways to manipulate HIPK2 activity is an interesting option to affect several biological pathways [23].
Apoptosis of neuronal and epithelial cells also triggers CD46 MMP-dependent shedding [33], [34], indicating that several biological pathways use this mechanism of regulation.
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Childhood trauma interacts with several genes belonging to several different biological pathways [Hypothalamic pituitary adrenal (HPA) axis, serotonergic transmission, neuroplasticity, immunity, calcium signaling, and circadian rhythms] to decrease the age at the onset of the disorder or increase the risk of suicide.
Identifying several genetic loci revealed that several important biological pathways are involved in AMD pathogenesis, such as the cholesterol, lipid metabolism pathway, complement pathway, extracellular matrix pathway, oxidative stress pathway, and angiogenesis signaling pathway in [ 20– 22], which provides a foundation for systematically analyzing the biological processes underlying AMD.
Genes with high regulatory event frequency (up + down > 0.8) were annotated with their involved KEGG pathways [ 25], and the most annotated pathways are listed in Additional file 3. Several biological signaling pathways are highlighted, including the Toll-like receptor, JAK-STAT, MAPK and T cell receptor signaling pathway.
The cumulative evidence shows several parallel biological pathways comprising the net nitrification process.
Analysis of 3SEQ data from both fresh tissue and FFPET revealed several additional biological pathways (acute myeloid leukemia, VEGF signaling pathway, oxidative phosphorylation), which are known to play important roles in oncogenesis in other tumors but whose contribution to SFT pathogenesis has not previously been described.
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