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In general, PCSKs are ubiquitously expressed and mediate numerous pathophysiological processes [ 129, 130], such as the conversion of inactive precursor proteins into biologically active products that are vital for several biological functions.
Anandamide (AEA) is an endocannabinoid operative in several biological functions.
Several biological functions including the mitochondrial protective properties are attributed to this peptide.
Quercetin is a bioflavonoid that exhibits several biological functions in vitro and in vivo.
Bacterial MVs are involved in several biological functions, such as delivery of cargo, virulence and gene transfer.
The presenilins are involved in several biological functions, but are best known for their role in the generation of the β-amyloid (Aβ) peptide in Alzheimer's disease and are therefore thought to be important drug targets for this disorder.
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone secreted by the pineal gland of mammals at nighttime, and it is involved in the regulation of the sleep-wake cycle as well as in several biological functions, including the regulation of mood, the control of seasonal reproduction, and the circadian rhythm, in animals and humans.
DUBs participate in the regulation of several biological functions.
Theoretically time delay is known to be the source of instability, and has been attributed to lead to oscillations or transient dynamics in several biological functions.
Accordingly, CRT has been associated with several biological functions, its roles as a lectin/chaperone in the folding of glycoproteins and as calcium buffer within the ER being the most prominent.
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As shown in Table 1 and Additional file 3, genes containing the INR+FPR supramotif in their promoters were enriched for several biological function and molecular process terms, most of which relate to pathogenesis.
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