Sentence examples for several binding motifs from inspiring English sources
This observation is in concordance with accepted models where the presence of several binding motifs close to each other increases the probability that the transcription factor spends more time bound to a particular region [16].
P1 is characterized by the longest isoform-specific first exon-encoded sequence (180 amino acid residues) and it contains several binding motifs for interaction with distinct molecules.
Several binding motifs for FOXO proteins were highly significantly enriched (q-value = 0.003 or less): for SOX2, multiple sites were present within 2 kb of the transcriptional start site.
Next, we compared these motifs with all known sequence-specific recognition elements of transcription factors, which led to the identification of several binding motifs of well-known adipogenic transcription factors including PPARγ and C/EBPγ (Ge et al., 2008).
While it is easy to create a single binding sequence by point mutation, the appearance of a combination of several binding motifs in an extended region of DNA is definitely more unlikely in this way.
The YAP1 protein contains several binding motifs which allow for protein-protein interactions; for example the WW domain (present in either single or dual form due to splicing events [ 3]) which can bind and regulate proteins by interaction with a proline rich PPxY motif.
Several binding site motifs were enriched in a compound-specific manner, including strong enrichment of the PPAR-gamma motif in genes regulated by compound H. Intriguingly, genes dysregulated by compounds K, L, N, P and Q were enriched for p53 binding sites, suggesting these compounds may induce p53-dependent apoptosis.
We also found several putative binding motifs for the co-factors of DAF-16 in regulating lifespan.
For the CTCF (an insulator in the regulation of transcription), several alternative binding motifs were detected.
Furthermore, CisFinder identified several alternative binding motifs for CTCF (b e), including three palindromes (b d).
Analyzing the primary sequence of the MeCP2e1 protein, we detected several p300 binding motifs.
