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This observation was surprising in view of previous publications on the pathogenic yeast Candida albicans, and several bacterial pathogens; NETs were found to be efficient weapons in PMN-mediated microbial killing [34], [64], [65].
Several bacterial pathogens for humans, such as legionella, mycobacteria and salmonella, are pathogenic also for Dictyostelium, favouring the use of this model to study host-pathogen interactions [ 9- 19].
Laboratory examinations revealed the presence of several bacterial pathogens in 15 of the 17 bronchoalveolar lavage samples, while no pathogenic bacteria were detected in the two remaining samples.
Quorum sensing is responsible for controlling a plethora of virulence genes in several bacterial pathogens.
'Hijacking' of host molecules is a strategy used by several bacterial pathogens to facilitate adhesion and/or to evade the host's immune response8,9.
Type IV transporters are produced by several bacterial pathogens such as Agrobacterium tumefaciens, Bordetella pertussis, Brucella spp., Bartonella henselae, Helicobacter pylori and Legionella pneumophila.
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Routine phage lysis assays including phage typing are still actively used for the detection and identification of various bacterial pathogens [28] [32] but several new phage-based technologies have been developed for more rapid and efficient detection of medically important bacteria.
The PhoPR system regulates expression of various genes involved in metabolic, virulence and resistance processes in several intracellular bacterial pathogens [44].
The synthesized peptides were tested for in vitro activity against several prototype bacterial pathogens using standardized laboratory procedures.
Examples of different adhesive mechanisms utilized by several key bacterial pathogens that cause detrimental biofilms on medical devices are described.
Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis.
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