Sentence examples for several apoptotic pathways from inspiring English sources

In HSC-3 cells, members of the caspase family, cytochrome c, and I κB α were upregulated, indicating that SIN causes oncolysis by activating several apoptotic pathways.

Conceptual advance comes from our finding that PON2 modulates execution of the cell death program directly at the mitochondria, thereby allowing modification of several apoptotic pathways converging at these organelles.

It is well known that ER may act as a critical control point in several apoptotic pathways activated by stimuli that cause a Ca2+ overload or perturb the Ca2+ homeostasis.

Together, the available data point to the existence of several apoptotic pathways that can be triggered by the compound, and to the existence of survival pathways that can be inhibited by it.

The mechanism of cell death involves, on the one hand, the activation of several apoptotic pathways [ 22] and on the other hand the necrotic cell death, probably caused by glutamate-mediated excitotoxicity [ 2, 6].

Bax, a promoting factor, Bcl2, which can prevent apoptosis, caspase-9, the initiator caspase for the activation of downstream caspases, and caspase-3, a factor in downstream of several apoptotic pathways [ 16], were analyzed with western blotting on days 3 and 7 after CCI.

These proteins play roles in several different apoptotic pathways.

Several distinct apoptotic pathways induced by photooxidative stress have recently been established (Oleinick et al, 2002).

The cleavage of host cell proteins results in cell death via several necrotic and apoptotic pathways, possibly leading to depletion of CD4+ T-cells.

Indeed, apoptosis is the first preferred mechanism of death in our system and it is triggered by at least four different pathways, whose independent temporal activation ensures cell killing when one or several of the apoptotic pathways are inactivated.

Human HSCs in their MF-like phenotype are characterised by the activation of several anti-apoptotic pathways.