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Looking beyond the websites that are well-known to us based on earlier findings, Fig. 4 uncovers several additional domains.
We also tested several additional domains, including MRG, BRK, SWIRM, and PWWP domains, but no binding was detected.
Both enzymes share two protein domains, but IMP dehydrogenase also includes a long N-terminal extension, incorporating several additional domains.
One interesting eukaryotic sequence from Branchiostoma floridae includes several additional domains that might hint at components involved in the eukaryotic fic domain signaling process.
Many other VSPs had weak hits to these three domains and several additional domains (TIL and Furin-like) that are also cysteine rich.
Each TF family was characterized by at least one DNA-binding domain and one or several additional domains involved in effector sensing and/or dimerization.
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We then present several additional task domains where H3Viewer was used, and conclude by summarizing the outcomes of the project.
We then discuss several additional task domains where people have chosen to use the H3 system, ranging from simply creating data files in the H3 format for quick perusal to creating custom applications using our libraries.
Several additional Pfam domains were also manually incorporated into the dictionary to predict more CAZymes.
The detailed analysis of these toxin systems and their immunity proteins further pointed to several additional examples of domains from them being acquired by eukaryotes and their viruses.
All PRMTs contain a conserved catalytic core region of approximately 310 amino acids, and several PRMTs possess additional domains (e.g., SH3, Zn finger, TIM barrel, and TPR) that have been suggested to diversify the substrate specificity of the enzymes and to regulate their activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com