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Zanetti et al. found that BMLs in the knee in subjects with severe OA undergoing total knee replacement consisted of several abnormalities including bone marrow necrosis, abnormal trabeculae, bone marrow fibrosis, bone marrow bleeding, and bone marrow oedema [ 8].
Mice with a homozygous deletion of Myh11 showed several abnormalities, including a giant and thin-walled bladder and abnormal intestinal movement, the core features of MMIHS.
Mice expressing the unedited serotonin receptors developed normally, but mice expressing the edited version presented with several abnormalities, including growth retardation and hyperphagia.
Mice deficient for H2A.X are viable but display several abnormalities including accumulation of chromosomal aberrations during M phase, G2/M checkpoint defects and enhanced radio-sensitivity [91 93].
Identification of a CSP is considered part of a standard evaluation during fetal sonography, and its absence is associated with several abnormalities including septo-optic dysplasia, abnormalities of the corpus callosum, and hydrocephalus.
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The several abnormalities include facial dysmorphia (arched eyebrows, synophrys, depressed nasal bridge, long philtrum, down-turned angles of the mouth), upper-extremity malformations, hirsutism, cardiac defects, and gastrointestinal alterations.
Similar supernumerary chromosomes in humans have been linked to several developmental abnormalities, including delayed mental growth, sterility, and various nonspecific neurological disorders (Wisniewski et al. 1979; Wisniewski and Doherty 1985; Fuster et al. 2004).
Several chromosomal abnormalities, including Down syndrome, have also been related to heart disease or malformations.
Both diseases share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and deposition of amyloidogenic proteins.
In peritoneal dialysis, the high glucose load absorbed from dialysis fluid contributes to several metabolic abnormalities, including insulin resistance.
Children with Prader Willi Syndrome (PWS) have several sleep abnormalities, including reduced REM sleep, altered sleep structure, oxygen desaturation and both central and obstructive apnea.
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CEO of Professional Science Editing for Scientists @ prosciediting.com